Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study
Mike Y Osei-Atweneboana, Jeffrey KL Eng, Daniel A Boakye,John O Gyapong and Roger K Prichard.
Interpretation
Ivermectin remains a potent microfilaricide. However our results suggest that resistant adult parasite populations, which are not responding as expected to ivermectin, are emerging. A high rate of repopulation of skin with microfilariae will allow parasite transmission, probably with ivermectin-resistant O volvulus, which could eventually lead to recrudescence of the disease.
Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study. The Lancet 2007; 369:2021-2029
